STEREOSELECTIVE PARTIAL SYNTHESIS OF (+)-PISIFERIC ACID

被引：22

作者：

GEIWIZ, J

HASLINGER, E

机构：

[1] HOFFMANN LA ROCHE AG,CH-4002 BASEL,SWITZERLAND

[2] GRAZ UNIV,INST PHARMAZEUT CHEM,UNIV PL 1,A-8010 GRAZ,AUSTRIA

来源：

HELVETICA CHIMICA ACTA | 1995年 / 78卷 / 04期

关键词：

D O I：

10.1002/hlca.19950780404

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(+)-Pisiferic acid (1), an antibiotic active against Gram-negative and Gram-positive bacteria, was synthesized starting from dehydroabietic acid (2) or abietic acid (26). The terpene ring system was functionalized and a Barton reaction used to oxidize Me(20). The intermediates of this photochemical reaction were isolated and characterized.

引用

页码：818 / 832

页数：15

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