EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF PROSTAGLANDIN-I2, PROSTAGLANDIN-E2, PROSTAGLANDIN-F2-ALPHA AND INDOMETHACIN ON BLOOD-PRESSURE IN THE RAT

The effects of intraventricularly administered prostaglandins I2 (PGI2), E2 (PGE2), F2α (PGF2α) and indomethacin on systemic blood pressure were investigated in conscious rats. PGI2 (1.25 - 10 g/kg) decreased blood pressure in a dose-related manner, whereas PGE2 (100 - 1000 ng/kg) dose-dependently increased blood pressure. Both PGF2α (0.31 - 20 μg/kg) and indomethacin (0.625 - 40 μg/kg) had no effects on blood pressure. These results indicate that intraventricular injection of PGI2 or PGE2 can induce significant changes in blood pressure, while endogenous prostaglandins synthesized in the brain seem to play a minor role in direct regulation of systemic blood pressure in the rat. © 1979.