INDUCTION OF HUMORAL MANIFESTATIONS OF AUTOIMMUNITY FOLLOWING INTRAPERITONEAL INJECTION OF COMPLETE FREUNDS-ADJUVANT IN MICE

被引：5

作者：

FAWCETT, PT

DUBBS, SB

FAWCETT, LB

DOUGHTY, RA

机构：

[1] Alfred I. duPont Institute, Wilmington, DE

[2] Department of Biological Science, University of Delaware, Wilmington, DE

来源：

AUTOIMMUNITY | 1990年 / 6卷 / 04期

关键词：

Adjuvant induced autoantibodies; Humoral autoimmunity;

D O I：

10.3109/08916939008998417

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several animal models of arthritis are produced using complete Freund's adjuvant (CFA) alone or with collagen as an arthritogen. Successful induction of arthritis is reported to require that the adjuvant mixture be administered by intradermal or subcutaneous routes. The resulting arthritis is caused by primarily cellular immune responses. Data presented in this paper show that giving CFA by intraperitoneal (I.P.) inoculation results in a humoral autoimmune response, with no obvious signs of arthritis. This humoral autoimmune response is characterized by production of autoantibodies to nuclear and cytoplasmic antigens, elevated levels of circulating immune complexes, and in approximately 25% of mice, rheumatoid factor. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：249 / 256

页数：8

共 25 条

[1]

Whitehouse M.W., Adjuvant-induced polyarthritis in Rats, Handbook of Animal Models for the Rheumatic Diseases, 1, pp. 3-16, (1988)

[2]

Van Eden W., Holoshitz J., Cohen I., Antigenic mimicry between mycobacteria and cartilage proteoglycans, Concepts In Immunopathology, 4, pp. 144-170, (1987)

[3]

Panosian N., Heyner S., Copetola R.A., Oryechowski R.F., Humoral and cellular immunologic aspects of adjuvant and collagen arthritis in rats, J Immunopharmacology, 8, pp. 347-370, (1986)

[4]

Cremer M., Type II Collagen-induced arthritis in rats, Handbook of Animal Models for the Rheumatic Diseases, 1, pp. 17-32, (1988)

[5]

Cremer M.D., Townes A.S., Kang A.H., Collagen-induced arthritis in rodents, The Ryumachi, 24, pp. 45-56, (1984)

[6]

Cooke T.D.U., Antigen-induced arthritis polyarthritis and tenosynovitis, Handbook of Animal Models for the Rheumatic Diseases, 1, pp. 53-81, (1988)

[7]

Kaibara N., Hotokebuchi T., Takagishi K., Katasuki I., Morinaga M., Arita C., Jingushi S., Pathogenetic difference between collagen arthritis and adjuvant arthritis, J Exp Med, 159, pp. 1296-1388, (1984)

[8]

Reinisch C.L., Induction of immunoregulatory T cells by adjuvant, Isr J Med Sci, 14, pp. 89-97, (1978)

[9]

Van deWater J., Gerschwin M.E., Avian Scleroderma, Handbook of Animal Models for the Rheumatic Diseases, 1, pp. 195-204, (1988)

[10]

Kerwar S.S., Ridge S.C., Oronsky A.L., Comparative studies between adjuvant Type II collagen and streptoccoccal cell wall-induced arthritis in rats, Handbook of Animal Models for the Rheumatic Diseases, 1, pp. 49-52, (1988)

← 1 2 3 →