ELABORATION AND CHARACTERIZATION OF THE DIAZEPAMPOLYETHYLENEGLYCOL 6000 SOLID DISPERSIONS

被引：13

作者：

GINES, JM

SANCHEZSOTO, PJ

JUSTO, A

VELA, MT

RABASCO, AM

机构：

[1] CSIC,INST RECURSOS NAT & AGROBIOL,SEVILLE,SPAIN

[2] UNIV SEVILLE,CSIC,INST CIENCIA MAT,SEVILLE,SPAIN

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 15期

关键词：

D O I：

10.3109/03639049009043800

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diazepam-polyethyleneglycol 6000 solid dispersions systems were prepared by melting and solvent methods. These dispersions were characterized using D.T.A., X-Ray diffraction and microscopy. The phase diagram has shown that this system is characterized as a simple eutectic mixture with a eutectic composition of 87% diazepam and 13% P.E.G. 6000. Solubility studies showed a linear increase in drug solubility with the increase of PE.G. 6000 concentration. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：2283 / 2301

页数：19

共 16 条

[1]

CHEMTOB C, 1985, STP PHARMA, V1, P531

[2] PHARMACEUTICAL APPLICATIONS OF SOLID DISPERSION SYSTEMS [J].

CHIOU, WL ;

RIEGELMAN, S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (09) :1281-+

[3] SIMILARITIES IN THE RELEASE RATES OF DIFFERENT DRUGS FROM POLYETHYLENE-GLYCOL 6000 SOLID DISPERSIONS [J].

DUBOIS, JL ;

FORD, JL .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (07) :494-495

[4]

DUBOIS JL, 1985, STP PHARM, V1, P711

[5]

ELBANNA HM, 1980, PHARM ACTA HELV, V55, P256

[6]

FORD JL, 1986, PHARM ACTA HELV, V61, P69

[7]

FORD JL, 1984, PHARM ACTA HELV, V59, P280

[8]

GHALY GM, 1986, STP PHARM, V2, P209

[9]

GINES JM, 1988, THESIS U SEVILLA

[10]

MURA P, 1987, Farmaco Edizione Pratica, V42, P149

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