IMMUNOCHEMICAL TECHNIQUES IN BIOLOGICAL MONITORING

被引:14
作者
ROSNER, MH
GRASSMAN, JA
HAAS, RA
机构
[1] CALIF DEPT HLTH SERV,AIR & IND HYG LAB,2151 BERKELEY WAY,BERKELEY,CA 94704
[2] CALIF PUBL HLTH FDN,BERKELEY,CA 94704
关键词
D O I
10.2307/3431306
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Immunoassays are analytical methods that detect interactions between antibodies and antigens. Immunoassays were used originally to detect large biological molecules. The new generation of these antibody-based assays can detect small synthetic compounds. As a result, immunoassays are being developed specifically for biomarkers of exposure and effect to environmentally prevalent chemicals. Immunochemical detection of parent compounds in blood and tissues, metabolites in excreta, and adducts with DNA and protein have been successfully performed by several investigators. Although there is great potential for use of immunossays in biological monitoring studies, the limitations of these analyses must be fully understood to prevent improper evaluation of the acquired data. This review will cover some of the background material necessary to understand how an antibody-based assay is developed. The differences between polyclonal and monoclonal antibody-based assays and the importance of antibody class, affinity, specificity, and cross-reactivity must be considered in both study design and data analysis.
引用
收藏
页码:131 / 134
页数:4
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