RENAL-TRANSPLANTATION IN PATIENTS WITH CLASSICAL HEMOLYTIC-UREMIC SYNDROME

被引：34

作者：

BASSANI, CE ^{[1
]}

FERRARIS, J ^{[1
]}

GIANANTONIO, CA ^{[1
]}

RUIZ, S ^{[1
]}

RAMIREZ, J ^{[1
]}

机构：

[1] HOSP ITALIANO BUENOS AIRES,DEPT PAEDIAT,NEPHROL SECT,RA-1181 BUENOS AIRES,ARGENTINA

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 05期

关键词：

HEMOLYTIC-UREMIC SYNDROME; RENAL TRANSPLANT; RECURRENCE IN THE ALLOGRAFT; POSTTRANSPLANT EVOLUTION;

D O I：

10.1007/BF00856651

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Eighteen records from children with renal transplants (RT) and classical haemolytic-uraemic syndrome (HUS) were reviewed. The mean oliguric period was 17.9 +/- 7.5 days; the interval between acute phase and end-stage renal disease (ESRD) was 9.3 +/- 5.2 years. HUS was the most frequent cause of renal transplantation (23.4%). There were no significant differences between patients with HUS and controls (children with RT but without HUS), regarding renal function, frequency of rejections, renal survival (HUS 65%, controls 57%) or patient survival (94.4% and 96.6%, respectively) after 9 years. None had clinical or histopathological evidence of HUS recurrence in the allograft. Of all children with living-related donors (LRD), renal survival after 3 years was longer for those who received cyclosporin A (CSA) (HUS and controls 86%) than for those who did not receive it (HUS 50%, controls 53%). Classical HUS is a frequent cause of ESRD in Argentina. The duration of the acute oliguric period is a good predictor of the likelihood of progression to chronicity. In the classical form of HUS there is no recurrence in the allograft. CSA and LRD can be used without risk in renal transplantation of children with classical HUS.

引用

页码：607 / 611

页数：5

共 22 条

[1]

Gianantonio C.A., Vitacco M., Mendilaharzu F., Gallo G., The hemolytic uremic syndrome. Renal status of 76 patients at long term follow-up, J Pediatr, 72, pp. 757-765, (1968)

[2]

McCrory W., A new cause for an old disease-chronic nephritis, The Journal of Pediatrics, 72, pp. 912-914, (1968)

[3]

Gianantonio C.A., Vitacco M., Mendilaharzu F., Gallo G.E., Sojo E.T., The hemolytic uremic syndrome, Nephron, 11, pp. 174-192, (1973)

[4]

Gianantonio C.A., Vitacco M., Mendilaharzu F., The hemolyticuremic syndrome, pp. 24-36, (1966)

[5]

Hebert D., Sibley R.K., Mauer S.M., Recurrence of hemolytic uremic syndrome in renal transplant recipient, Kidney Int, 30, pp. S51-S58, (1986)

[6]

Remuzzi G., Nephrology forum: HUS and TTP: variable expression of a single entity, Kidney Int, 32, pp. 292-308, (1987)

[7]

Strom T.B., McCluskey R.T., Renal disorder 13 months after renal transplantation for the hemolytic uremic syndrome, N Engl J Med, 314, pp. 1032-1040, (1986)

[8]

Lerilli G.S., Nelsen C., Dorfmann L., Renal homotransplantation in infants and children with the hemolytic uremic syndrome, Surgry, 71, pp. 66-71, (1972)

[9]

Folman R., Arbus G.S., Churchill B., Gaum L., Huber J., Recurrence of the hemolytic uremic syndrome in a 3 1/2 year old child, 4 months after second renal transplantation, Clin Nephrol, 10, pp. 121-127, (1978)

[10]

Gianantonio C.A., Past and present of the hemolytic uremic syndrome in Argentina, Acute renal disorders and renal emergencies, pp. 13-20, (1984)

← 1 2 3 →