IMMUNOMODULATORY EFFECT OF INTERFERON-ALPHA-2B ON NATURAL-KILLER-CELLS AND LYMPHOCYTES-T FROM PATIENTS WITH TRANSITIONAL CELL-CARCINOMA OF THE BLADDER

被引：9

作者：

ALVAREZMON, M ^{[1
]}

MOLTO, LM ^{[1
]}

MANZANO, L ^{[1
]}

OLIVIER, C ^{[1
]}

CARBALLIDO, JA ^{[1
]}

机构：

[1] CLIN PUERTA HIERRO, DEPT SURG, SERV UROL, MADRID, SPAIN

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷

关键词：

BLADDER CANCER; CYTOTOXICITY; INTERFERON-ALPHA-2B; MONONUCLEAR CELLS; NATURAL KILLER CELLS; LYMPHOCYTES-T;

D O I：

10.1097/00001813-199205000-00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Incubation of peripheral blood mononuclear cells (PBMNC) from patients with transitional cell carclnoma of the bladder, with interferon (IFN-alpha-2b) causes dose-dependent enhancement of natural killer (NK) and cytotoxic activity. Increased lytic activity was also observed against both NK-sensitive and NK-resistant target cells and T lymphocytes from such patients showed altered activity upon incubation with IFN-alpha-2b. Furthermore, intracavitary instillation of IFN-alpha-2b is associated with infiltration of the bladder wall by NK cells and T lymphocytes. Future work will be aimed at investigating the possible prognostic value of these results as related to the therapeutic effect of intracavitary instillation of IFN-alpha-2b.

引用

页码：5 / 8

页数：4

共 27 条

[1]

Alvarez de Mon M, 1987, Med Clin (Barc), V89, P387

[2]

ALVAREZMON M, 1987, EUR J HAEMATOL, V38, P268

[3]

ALVAREZMON M, 1990, DRUG TODAY, V26, P109

[4]

BALKWILL FR, 1989, LANCET, V1, P1060

[5]

BARLOZZARI T, 1985, J IMMUNOL, V134, P2783

[6]

BONILLA F, 1988, CANCER, V61, P629, DOI 10.1002/1097-0142(19880215)61:4<629::AID-CNCR2820610402>3.0.CO

[7]

2-V

[8] CLINICAL-SIGNIFICANCE OF NATURAL-KILLER ACTIVITY IN PATIENTS WITH TRANSITIONAL CELL-CARCINOMA OF THE BLADDER [J].

CARBALLIDO, J ;

ALVAREZMON, M ;

SOLOVERA, J ;

MENENDEZONDINA, L ;

DURANTEZ, A .

JOURNAL OF UROLOGY, 1990, 143 (01) :29-33

[9]

CARBALLIDO J, 1991, INMUNOTERAPIA CON IN, P5

[10]

CARBALLIDO J, 1991, IMMUNOTERAPIA CON IN, P19

← 1 2 3 →