RENAL-FAILURE DUE TO BK VIRUS-INFECTION IN AN IMMUNODEFICIENT CHILD

被引:39
作者
DESILVA, LM
BALE, P
DECOURCY, J
BROWN, D
KNOWLES, W
机构
[1] CHILDRENS HOSP,DEPT HISTOPATHOL,CAMPERDOWN,NSW 2050,AUSTRALIA
[2] CHILDRENS HOSP,DEPT ONCOL,CAMPERDOWN,NSW 2050,AUSTRALIA
[3] CENT PUBL HLTH LAB,DIV VIRUS REFERENCE,LONDON NW9 5HT,ENGLAND
关键词
IMMUNOCOMPROMISED PATIENT; POLYOMAVIRUS; RENAL FAILURE;
D O I
10.1002/jmv.1890450214
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We report a child with cartilage-hair hypoplasia and Hodgkin's disease who developed progressive renal failure and died following infection with a polyomavirus, BK virus. Renal biopsy showed interstitial inflammation, tubular atrophy, and intranuclear inclusions in tubular epithelium, with large numbers of papovavirus particles within the cells. BK virus infection was confirmed by polymerase chain reaction on renal biopsy material and in urine and the demonstration of a high titre of haemagglutination inhibition (HI) and IgM antibody to the virus in the patient's serum. This case emphasises the need to study in depth any unusual clinical manifestation in immunocompromised patients to delineate better the full clinical impact of less well-established pathogens such as BK virus. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:192 / 196
页数:5
相关论文
共 13 条
[1]   LATE-ONSET HEMORRHAGIC CYSTITIS ASSOCIATED WITH URINARY-EXCRETION OF POLYOMAVIRUSES AFTER BONE-MARROW TRANSPLANTATION [J].
APPERLEY, JF ;
RICE, SJ ;
BISHOP, JA ;
CHIA, YC ;
KRAUSZ, T ;
GARDNER, SD ;
GOLDMAN, JM .
TRANSPLANTATION, 1987, 43 (01) :108-112
[2]   ASSOCIATION OF BK VIRURIA WITH HEMORRHAGIC CYSTITIS IN RECIPIENTS OF BONE-MARROW TRANSPLANTS [J].
ARTHUR, RR ;
SHAH, KV ;
BAUST, SJ ;
SANTOS, GW ;
SARAL, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (04) :230-234
[3]  
ARTHUR RR, 1988, LABORATORY DIAGNOSIS, V11, P317
[4]   RAPID AND SIMPLE METHOD FOR PURIFICATION OF NUCLEIC-ACIDS [J].
BOOM, R ;
SOL, CJA ;
SALIMANS, MMM ;
JANSEN, CL ;
WERTHEIMVANDILLEN, PME ;
VANDERNOORDAA, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (03) :495-503
[5]   BK VIRUS SPECIFIC IGM RESPONSES IN CORD SERA, YOUNG-CHILDREN AND HEALTHY-ADULTS DETECTED BY RIA [J].
BROWN, DWG ;
GARDNER, SD ;
GIBSON, PE ;
FIELD, AM .
ARCHIVES OF VIROLOGY, 1984, 82 (3-4) :149-160
[6]   HUMAN POLYOMAVIRUS (BK) INFECTION AND URETERIC STENOSIS IN RENAL-ALLOGRAFT RECIPIENTS [J].
COLEMAN, DV ;
MACKENZIE, EFD ;
GARDNER, SD ;
POULDING, JM ;
AMER, B ;
RUSSELL, WJI .
JOURNAL OF CLINICAL PATHOLOGY, 1978, 31 (04) :338-347
[7]   DETECTION OF JC VIRUS-DNA IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].
GIBSON, PE ;
KNOWLES, WA ;
HAND, JF ;
BROWN, DWG .
JOURNAL OF MEDICAL VIROLOGY, 1993, 39 (04) :278-281
[8]   THE ROLE OF BK VIRUS IN ACUTE RESPIRATORY-TRACT DISEASE AND THE PRESENCE OF BKV DNA IN TONSILS [J].
GOUDSMIT, J ;
WERTHEIMVANDILLEN, P ;
VANSTRIEN, A ;
VANDERNOORDAA, J .
JOURNAL OF MEDICAL VIROLOGY, 1982, 10 (02) :91-99
[9]  
HOGAN TF, 1990, TXB HUMAN VIROLOGY, P970
[10]   AN M-ANTIBODY CAPTURE RADIOIMMUNOASSAY (MACRIA) FOR DETECTION OF JC VIRUS-SPECIFIC IGM [J].
KNOWLES, WA ;
GIBSON, PE ;
HAND, JF ;
BROWN, DWG .
JOURNAL OF VIROLOGICAL METHODS, 1992, 40 (01) :95-105