CHEMILUMINESCENCE DETERMINATION OF SOME LOCAL-ANESTHETICS

被引：51

作者：

ZHANG, XR

BAEYENS, WRG

VANDERWEKEN, G

CALOKERINOS, AC

IMAI, K

机构：

[1] STATE UNIV GHENT,FAC PHARMACEUT SCI,DEPT PHARMACEUT ANAL,DRUG QUAL CONTROL LAB,B-9000 GHENT,BELGIUM

[2] SHAANXI NORMAL UNIV,DEPT CHEM,XIAN 710062,PEOPLES R CHINA

[3] UNIV ATHENS,DEPT CHEM,ANALYT CHEM LAB,GR-15771 ATHENS,GREECE

[4] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT ANALYT CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

ANALYTICA CHIMICA ACTA | 1995年 / 303卷 / 01期

关键词：

CHEMILUMINESCENCE; LOCAL ANESTHETICS; PHARMACEUTICAL ANALYSIS;

D O I：

10.1016/0003-2670(94)00517-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The analytical possibilities of the chemiluminescence observed from some local anaesthetics on acidic permanganate treatment are investigated. Five drugs belonging to the p-aminobenzoate series gave significant emission and the reagent concentrations for their determination were optimized. The following detection limits were obtained: benzocaine, 30 ng ml(-1); butacaine, 20 ng ml(-1); butoform, 30 ng ml(-1); procaine, 40 ng ml(-1) and tetracaine 3 ng ml(-1). The application of the reaction to the analysis of some pharmaceutical preparations containing benzocaine and procaine was evaluated.

引用

页码：137 / 142

页数：6

共 29 条

[1] DETERMINATION OF MORPHINE IN BODY-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH CHEMILUMINESCENCE DETECTION [J].