INDUCTION OF SISTER CHROMATID EXCHANGES AND CHROMOSOME-ABERRATIONS IN CULTURED MAMMALIAN-CELLS BY N-NITROSOCIMETIDINE

被引：15

作者：

ATHANASIOU, K ^{[1
]}

KYRTOPOULOS, SA ^{[1
]}

机构：

[1] NATL HELLENIC RES FDN, BIOL RES CTR, 48 VASSILEOS CONSTANTINOU AVE, GR-701 ATHENS, GREECE

来源：

CANCER LETTERS | 1981年 / 14卷 / 01期

关键词：

D O I：

10.1016/0304-3835(81)90011-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N-Nitrosocimetidine (NC) [a metabolite of the antiulcer agent cimetidine] induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 .times. 10-7 M. Its effectiveness in SCE induction is about 2/3 that of the gastric carcinogen N-methyl-N''-nitro-N-nitrosoguanidine (MNNG). Apparently NC possesses carcinogenic activity.

引用

页码：71 / 75

页数：5

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