FIBRINOGEN AND AGING

被引：40

作者：

HAGER, K

FELICETTI, M

SEEFRIED, G

PLATT, D

机构：

[1] University of Erlangen-Nürnberg, Nürnberg

[2] Clinic for Medical Rehabilitation and Geriatrics, Hannover, D-30559

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 6卷 / 02期

关键词：

AGING; FIBRINOGEN; FIBRINOGEN D-DIMERS; CARDIOVASCULAR RISK FACTORS;

D O I：

10.1007/BF03324226

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Plasma fibrinogen concentration is becoming widely accepted as a risk factor for cardio- and cerebrovascular disease. In order to evaluate its age-dependency, plasma fibrinogen and several other blood components were determined in 156 persons (23-96 years). In 116 participants, living on their own and rating themselves as healthy, fibrinogen increased by 26 mg/dL and decade. After exclusion of persons with pathological laboratory findings and risk factors, fibrinogen still rose by 25 mg/dL per decade, thereby reaching concentrations above 320 mg/dL in 81% of those older than 65 years. In prospective studies, these values were found to be associated with an augmented cardio- and cerebrovascular risk. In this investigation, the age-dependent rise of fibrinogen was more pronounced than that of blood glucose or cholesterol. Increasing fibrinogen may reflect a multitude of processes, such as (occult) acute phase reactions, risk factors, subclinical degeneration of vascular endothelium, or a more frequent activation of coagulation and fibrinolysis, with interleukin 6 (IL-6) as a possible mediator

引用

页码：133 / 138

页数：6

共 28 条

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