A HIGHLY STEREOSELECTIVE GLYCOSYLATION OF 2-(PHENYLSELENENYL)-2,3-DIDEOXYRIBOSE DERIVATIVE WITH THYMINE - SYNTHESIS OF 3'-DEOXY-2',3'-DIDEHYDROTHYMIDINE AND 3'-DEOXYTHYMIDINE

被引:75
作者
CHU, CK
BABU, JR
BEACH, JW
AHN, SK
HUANG, HQ
JEONG, LS
LEE, SJ
机构
[1] Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Athens
关键词
D O I
10.1021/jo00292a006
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
: A highly stereoselective synthesis of 3'-deoxy'-didehydrothymidine (D4T) and 3’-deoxythymidine (D2T) was achieved from the condensation of 2-(phenylselenenyl)-2, 3-dideoxyribose derivative and silylated thymine in the presence of trimethylsilyl triflate. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:1418 / 1420
页数:3
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