INTERACTION OF CIGARETTE-SMOKING AND CHRONIC DRUG INGESTION ON HUMAN DRUG-METABOLISM

被引：5

作者：

COOKSLEY, WGE ^{[1
]}

FARRELL, GC ^{[1
]}

CASH, GA ^{[1
]}

POWELL, LW ^{[1
]}

机构：

[1] UNIV QUEENSLAND, ROYAL BRISBANE HOSP, DEPT MED, BRISBANE 4029, Qld, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 05期

关键词：

Antipyrine; cigarette smoking; drug metabolism; glutethimide;

D O I：

10.1111/j.1440-1681.1979.tb00035.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Drug metabolism was assessed by the disappearance rate of antipyrine as measured in saliva. Results were expressed in terms of both clearance and half life. 2. Basal measurements of antipyrine disappearance rate were performed in seven non‐smokers and six smokers. After administration of glutethimide 250 mg daily for 7 days a second measurement of antipyrine disappearance rate was made. 3. Glutethimide enhanced antipyrine metabolism in both smokers and non‐smokers. The degree of change in both groups was similar. 4. A similar study was carried out with a smaller dose (125 mg) of glutethimide. There was no significant difference between smokers and non‐smokers. 5. The data are consistent with smoking and chronic drug ingestion having additive effects on enhancement of hepatic drug metabolism. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：527 / 533

页数：7

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