ACYCLOGUANOSINE TREATMENT OF HERPESVIRUS INFECTIONS IN FOOTPADS AND NERVOUS-TISSUE OF NORMAL AND IMMUNOSUPPRESSED MICE

被引：7

作者：

MAYO, DR

RICHARDS, JC

RAPP, F

机构：

[1] PENN STATE UNIV, MILTON S HERSHEY MED CTR, COLL MED, DEPT MICROBIOL, HERSHEY, PA 17033 USA

[2] PENN STATE UNIV, MILTON S HERSHEY MED CTR, COLL MED, SPECIALIZED CANC RES CTR, HERSHEY, PA 17033 USA

来源：

INTERVIROLOGY | 1979年 / 12卷 / 06期

关键词：

D O I：

10.1159/000149095

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Treatment of herpes simplex virus type 1 (HSV-1)-infected mice with acycloguanosine resulted in significantly fewer virus isolates from nervous tissues than from tissues of untreated animals. Acycloguanosine also significantly reduced the mean titers of HSV-1 recovered from the footpads of drug-treated animals. The anti-herpetic activity of acycloguanosine was observed in both normal and immunosuppressed mice.

引用

页码：345 / 348

页数：4

共 11 条

[1]

Baringer J R, 1974, Adv Neurol, V6, P41

[2] PATHOGENESIS OF HERPETIC NEURITIS AND GANGLIONITIS IN MICE - EVIDENCE FOR INTRA-AXONAL TRANSPORT OF INFECTION [J].