NATURAL AND EXPERIMENTAL TRANSFER OF ANTIPERTUSSIS ANTIBODIES CONFERS RESISTANCE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

被引：5

作者：

BRENNER, T

ABRAMSKY, O

机构：

[1] Laboratory of Neuroimmunology, Department of Neurology, Hadassah-Hebrew University Hospital, Ein Kerem, Jerusalem

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 114卷 / 01期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PERTUSSIS VACCINE; LACTATION; ANTIPERTUSSIS ANTIBODIES; ANTIMYELIN BASIC PROTEIN ANTIBODIES;

D O I：

10.1016/0022-510X(93)90042-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pregnant rats challenged with Bordetela Pertussis vaccine, with or without encephalitogenic antigen during pregnancy, transferred a resistance to induction of experimental autoimmune encephalomyelitis (EAE) to their offspring. Cross-fostering experiments showed that the protection against EAE is conferred during the lactation period through the transfer of anti pertussis antibodies in the milk. The degree of protection correlated with antibody levels. Passive transfer of these antibodies through intraperitoneal injection to naive adult rats also confered the same degree of protection against EAE induction. It is suggested that such transfer of resistance and antibodies may serve as a model for the study of milk transmitted immunocompetent factors, as well as a model for the mechanisms involved in the resistance to EAE.

引用

页码：13 / 19

页数：7

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