STRUCTURAL REQUIREMENTS FOR BIOLOGICAL-ACTIVITY OF THE MARINE ALKALOID ASCIDIDEMIN

被引：54

作者：

LINDSAY, BS

BARROWS, LR

COPP, BR

机构：

[1] UNIV AUCKLAND,DEPT CHEM,AUCKLAND,NEW ZEALAND

[2] UNIV UTAH,COLL PHARM,DEPT PHARMACOL & TOXICOL,SALT LAKE CITY,UT 84112

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

关键词：

D O I：

10.1016/0960-894X(95)00106-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Comparison of the biological activities observed for ascididemin (2) and synthetic precursors/analogs has established the importance of N-8 in ring A, and a completed ring E, to topoisomerase II enzyme inhibition, human tumor cytotoxicity and antifungal/antibacterial properties. The results also suggest the presence of multiple mechanisms of toxicity by 2 towards mammalian cell systems.

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页码：739 / 742

页数：4

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