MEDIATION OF H2O2-INDUCED VASCULAR RELAXATION BY ENDOTHELIUM-DERIVED RELAXING FACTOR

被引：31

作者：

BHARADWAJ, L ^{[1
]}

PRASAD, K ^{[1
]}

机构：

[1] UNIV SASKATCHEWAN,COLL MED,DEPT PHYSIOL,SASKATOON,SK S7N 5E5,CANADA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1995年 / 149卷

关键词：

HYDROGEN PEROXIDE; RABBIT AORTA; N-G-MONOMETHYL-L-ARGININE; DEENDOTHELIALIZATION; GLUCOSE OXIDASE;

D O I：

10.1007/BF01076587

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the effects of H2O2 generated by glucose (G) and glucose oxidase (GO) on the isolated rabbit aorta suspended in Krebs-Ringer solution. H2O2 produced contraction in small concentration and relaxation followed by contraction in large concentration. Contraction produced by large concentration was smaller than that produced by small concentration of H2O2. Relaxation was prevented by deendothelialization or N-G-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis. These results suggest that H2O2 in large concentrations produces relaxation followed by contraction, and that the relaxation is endothelium-dependent and is mediated by nitric oxide, an endothelium-derived relaxing factor.

引用

页码：267 / 270

页数：4

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