BIOLOGICAL SAMPLE PREPARATION AND DATA REDUCTION CONCEPTS IN PHARMACEUTICAL ANALYSIS

被引：57

作者：

JOHNSON, EL ^{[1
]}

REYNOLDS, DL ^{[1
]}

WRIGHT, DS ^{[1
]}

PACHLA, LA ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,DIV PHARMACEUT RES,DEPT PHARMACOKINET DRUG METAB,ANN ARBOR,MI 48105

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1988年 / 26卷 / 08期

关键词：

CHEMICAL ANALYSIS - Robot Applications - DRUG PRODUCTS - Chromatographic Analysis;

D O I：

10.1093/chromsci/26.8.372

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A description is given of strategies to rapidly develop sensitive and selective preparations using manual and robotic liquid-solid isolation (LSI) methods. LSI procedures offer selective isolation of drug or metabolites from complex matrices and are applicable to many pharmaceutical compounds. The beneficial effect of weighted linear regression is described, and several data reduction techniques are contrasted.

引用

页码：372 / 379

页数：8

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