HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF SACCHARIN IN ARTIFICIAL SWEETENERS AND PHARMACEUTICALS

被引：5

作者：

PALERMO, PJ

TSAI, PSF

机构：

[1] Norwich-Eaton Pharmaceuticals, Norwich, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 07期

关键词：

High‐pressure liquid chromatography—analysis; saccharin in various artificial sweeteners and Pharmaceuticals; stability indicating; Saccharin—analysis; high‐pressure liquid chromatographic; in various artificial sweeteners and Pharmaceuticals; Stability—saccharin; various artificial sweeteners and Pharmaceuticals; high‐pressure liquid chromatography;

D O I：

10.1002/jps.2600680724

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A high‐pressure liquid chromatographic procedure is presented for determining saccharin in various formulations. The method is fast, precise, and accurate and is specific for saccharin in the presence of its most likely impurities and degradation products. Reversed‐phase chromatography on a micro‐C18 column is utilized with an internal standard, and detection is by UV absorption at 280 nm. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：878 / 880

页数：3

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