SIMPLE SYNTHESIS OF 1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL(1-DEOXYNOJIRIMYCIN) AND 1,6-DIDEOXY-1,6-IMINO-D-GLUCITOL FROM D-GLUCOFURANURONO-6,3-LACTONE

被引：76

作者：

DAX, K

GAIGG, B

GRASSBERGER, V

KOLBLINGER, B

STUTZ, AE

机构：

[1] Institut für Organische Chemie, Technische Universität Graz, GRAZ A-8010

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1990年 / 9卷 / 04期

关键词：

D O I：

10.1080/07328309008543848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

l,5-Dideoxy-l,5-imino-D-glucitol (1-deoxynojirimycin) and 1,6-dideoxy-l,6-imino-D-glucitol were synthesised by simple sequences in seven and six steps, respectively, from D-glucofuranurono-6,3-lactone. Attempts to improve the yield of the crucial regio- and stereospecific introduction of azide into position 5 of suitable derivatives of this substrate are described. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：479 / 499

页数：21

共 34 条

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