DDAVP FACTOR-VIII CONCENTRATE AND ITS PROPERTIES INVIVO AND INVITRO

被引:26
作者
NILSSON, IM
MIKAELSSON, M
VILHARDT, H
WALTER, H
机构
[1] BLOOD TRANSFUS CTR, STOCKHOLM, SWEDEN
[2] FERRING AB, DEPT RES, MALM, SWEDEN
[3] KABI AB, DEPT RES, STOCKHOLM, SWEDEN
关键词
D O I
10.1016/0049-3848(79)90072-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
DDAVP fraction I-0 was prepared from a plasma pool derived from 80 blood donors who had received DDAVP and tranexamic acid. A control fraction I-0 was prepared from a plasma pool from the same group of blood donors under identical conditions except for the drug treatment. The DDAVP plasma pool as well as the DDAVP fraction I-0 contained 2-3 times as much VIII:C as the controls. VIIIR:Ag increased to a lesser extent. No difference in stability of VIII:C was seen. In vivo studies showed that infusion of the DDAVP fraction I-0 to 3 patients with severe haemophilia A (<0.01 i.u. VIII:C/ml) caused a 2-3 times higher increase in VIII:C than after infusion of the same volume of the control fraction I-0. No difference in disappearance rate of VIII:C was seen. Both factor VIII concentrates normalised the prolonged bleeding time and caused a secondary VIII:C increase in VWD. It is concluded that administration of DDAVP to blood donors prior to collection of blood increases the content of VIII:C in the ensuing factor VIII concentrate and secondly, that such stimulation has no demonstrable qualitative effect on the factor VIII obtained. © 1979.
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页码:263 / 271
页数:9
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