GLUTATHIONE METABOLIC PATHWAY AS A SCAVENGING SYSTEM IN THE LENS

被引：17

作者：

RATHBUN, WB

HANSON, SK

机构：

[1] Department of Ophthalmology, University of Minnesota, Minneapolis, MN

来源：

OPHTHALMIC RESEARCH | 1979年 / 11卷 / 3-4期

关键词：

Detoxification; Glutathione; Glutathione peroxidase; Glutathione S-transferase; Glutathione-scavenging pathway; Hydroperoxide; Toxic agents;

D O I：

10.1159/000265003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glutathione peroxidase and glutathione S-transferase have been demonstrated in both bovine and human lenses. This has led to the formulation of a new 8-enzyme metabolic pathway for detoxification within the lens of electrophilic compounds and hydroperoxides of both extra- and intralenticular origin. © 1979 S. Karger AG, Basel.

引用

页码：172 / 176

页数：5

共 13 条

[1]

GORNALL AG, 1949, J BIOL CHEM, V177, P751

[2]

HABIG WH, 1974, J BIOL CHEM, V249, P7130

[3] AFFINITY CHROMATOGRAPHY IN PURIFICATION OF GLUTATHIONE REDUCTASE [J].