A POINT MUTATION IN A SHAKER K+ CHANNEL CHANGES ITS CHARYBDOTOXIN BINDING-SITE FROM LOW TO HIGH-AFFINITY

被引：71

作者：

GOLDSTEIN, SAN

MILLER, C

机构：

[1] Howard Hughes Medical Institute, Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts

来源：

BIOPHYSICAL JOURNAL | 1992年 / 62卷 / 01期

关键词：

D O I：

10.1016/S0006-3495(92)81760-5

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

[No abstract available]

引用

页码：5 / 7

页数：3

共 12 条

[1] 3-DIMENSIONAL STRUCTURE OF NATURAL CHARYBDOTOXIN IN AQUEOUS-SOLUTION BY H-1-NMR - CHARYBDOTOXIN POSSESSES A STRUCTURAL MOTIF FOUND IN OTHER SCORPION TOXINS
BONTEMS, F
ROUMESTAND, C
BOYOT, P
GILQUIN, B
DOLJANSKY, Y
MENEZ, A
TOMA, F
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 196 (01): : 19 - 28
[2] FUNCTIONAL-CHARACTERIZATION OF A MINIMAL K+ CHANNEL EXPRESSED FROM A SYNTHETIC GENE
HAUSDORFF, SF
GOLDSTEIN, SAN
RUSHIN, EE
MILLER, C
[J]. BIOCHEMISTRY, 1991, 30 (13) : 3341 - 3346
[3] RAPID AND EFFICIENT SITE-SPECIFIC MUTAGENESIS WITHOUT PHENOTYPIC SELECTION
KUNKEL, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (02) : 488 - 492
[4] MECHANISM OF CHARYBDOTOXIN BLOCK OF THE HIGH-CONDUCTANCE, CA-2+-ACTIVATED K+ CHANNEL
MACKINNON, R
MILLER, C
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1988, 91 (03) : 335 - 349
[5] MUTATIONS AFFECTING TEA BLOCKADE AND ION PERMEATION IN VOLTAGE-ACTIVATED K+ CHANNELS
MACKINNON, R
YELLEN, G
[J]. SCIENCE, 1990, 250 (4978) : 276 - 279
[6] MAPPING THE RECEPTOR-SITE FOR CHARYBDOTOXIN, A PORE-BLOCKING POTASSIUM CHANNEL INHIBITOR
MACKINNON, R
HEGINBOTHAM, L
ABRAMSON, T
[J]. NEURON, 1990, 5 (06) : 767 - 771
[7] COMPETITION FOR BLOCK OF A CA-2+-ACTIVATED K+ CHANNEL BY CHARYBDOTOXIN AND TETRAETHYLAMMONIUM
MILLER, C
[J]. NEURON, 1988, 1 (10) : 1003 - 1006
[8] OLIVA C, 1991, Biophysical Journal, V59, p450A
[9] DESIGN, SYNTHESIS, AND FUNCTIONAL EXPRESSION OF A GENE FOR CHARYBDOTOXIN, A PEPTIDE BLOCKER OF K+ CHANNELS
PARK, CS
HAUSDORFF, SF
MILLER, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2046 - 2050
[10] ROOT M J, 1991, Biophysical Journal, V59, p197A

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