B-CELL TOLERANCE

被引：32

作者：

GOODNOW, CC ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,BECKMAN CTR,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 06期

关键词：

D O I：

10.1016/0952-7915(92)90049-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates. The details of this developmental decision-making and the steps where it is prone to go awry in autoimmunity have yet to be untangled, but genetic analysis appears likely to lead the way.

引用

页码：703 / 710

页数：8

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