EVALUATION OF CATHEPSIN-D AS A PROGNOSTIC FACTOR IN BREAST-CANCER

被引:61
作者
RAVDIN, PM
机构
[1] Division of Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, 78284-7884, Texas
关键词
CATHEPSIN-D; BREAST NEOPLASMS; PROGNOSTIC MARKERS;
D O I
10.1007/BF01833262
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The biologic rationale for the importance of cathepsin D in breast cancer is a provocative one. Cathepsin D is both an estrogen inducible and a constitutively produced protease, which may also act directly as a peptide growth factor. Thus it may play a role in tumor invasiveness, and also in driving cell proliferation. Reported clinical studies are conflicting, with some studies showing cathepsin D levels to correlate with clinical outcome, and other studies finding prognostic significance only in selected subsets of patients, if any. Thus cathepsin D is a potentially important prognostic marker whose clinical application awaits further definition.
引用
收藏
页码:219 / 226
页数:8
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