STUDIES ON THE METABOLISM OF QUATERNARY PROTOBERBERINE ALKALOIDS IN CELL-CULTURES OF CORYDALIS-PALLIDA VAR TENUIS AND CORYDALIS-INCISA

被引:13
作者
IWASA, K
KONDOH, Y
KAMIGAUCHI, M
机构
[1] Kobe Pharmaceutical University, Higashinada, Kobe 658, 4-19-1, Motoyamakita
来源
JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 03期
关键词
D O I
10.1021/np50117a006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
An lc-apcims procedure was applied towards the identification of metabolites of quaternary protoberberine alkaloids in cultured cells of Corydalis species. Interconversions of tetrahydroprotoberberines [3 and 10] and protoberberinium salts [1 and 8] and those of cis- and trans-13-methyltetrahydroprotoberberines [14, 20, 18, 23] and 13-methylprotoberberinium salts [2 and 9] were demonstrated. The oxidation-reduction process of the C ring of protoberberines was confirmed. The corresponding alpha-N-metho sales [4, 11 or 15,and 19] having the B/C-cis ring junction were produced from tetrahydroprotoberberines [3, 10] or cis- and trans-13-methyltetrahydroprotoberberines [14 and 18]. Methylation at C-13 of the protoberberinium salts 1 and 8 afforded the 1 3-methylprotoberberinium salts 2 and 9.
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页码:379 / 391
页数:13
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