EFFECTS OF GROWTH-HORMONE ON KIDNEY-FUNCTION IN PEDIATRIC TRANSPLANT RECIPIENTS

被引：26

作者：

CHAVERS, BM

DOHERTY, L

NEVINS, TE

COOK, M

SANE, K

机构：

[1] Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, 55455, Minnesota

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 02期

关键词：

RECOMBINANT HUMAN GROWTH HORMONE; KIDNEY TRANSPLANTATION; REJECTION;

D O I：

10.1007/BF00860737

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Recent evidence suggests that treatment with recombinant human growth hormone (rhGH) after a successful kidney transplant improves the growth rate of children with short stature. We prospectively investigated eight children (6 boys, 2 girls), focusing on acute rejection episodes and changes in serum creatinine levels during rhGH treatment. The children (mean age 11.6+/-3.4 years) received rhGH daily (0.04-0.05 mg/kg subcutaneously). Seven patients completed at least 12 months (20+/-8 months) of rhGH treatment. Their mean serum creatinine level was 1.3 +/- 0.7 mg/dl 12 months before, and increased to 3.4+/-4.2 mg/dl after 12 months of rhGH treatment, but did not achieve statistical significance (P=0.06). Their mean calculated glomerular filtration rate was 58+/-20 ml/min per 1.73 m(2) 12 months before, and decreased to 38+/-21 ml/min per 1.73 m(2) after 12 months of rhGH treatment, but did not achieve statistical significance (P=0.08). Of the seven patients, two developed acute rejection after 5 and 6 rejection-free years; three lost their grafts and returned to dialysis. These preliminary observations describe untoward renal events in children receiving rhGH treatment after a kidney transplant.

引用

页码：176 / 181

页数：6

共 26 条

[1] Chavers B.M., Matas A.J., Nevins T.E., Mauer S.M., Sutherland D.E.R., Payne W., Dunn D., Gillingham K., Najarian J.S., Results of pediatric kidney transplantation at the University of Minnesota, Clinical transplants, pp. 253-266, (1989)
[2] McEnery P.T., Stablein D.M., Arbus G., Tejani A., Renal transplantation in children. A report of the North American Pediatric Renal Transplant Cooperative Study, N Engl J Med, 326, pp. 1727-1732, (1992)
[3] Ettenger R.B., Blifeld C., Prince H., Gradus D.B.E., Cho S., Seklya N., Salusky I.B., Fine R.N., The pediatric nephrologist's dilemma: growth after renal transplantation and its interaction with age as a possible immunologic variable, J Pediatr, 111, pp. 1022-1025, (1987)
[4] Offner G., Hoyer P.F., Juppner H., Krohn H.P., Brodehl J., Somatic growth after kidney transplantation. Beneficial effect of cyclosporine in comparison with conventional immunosuppression, Am J Dis Child, 141, pp. 541-546, (1987)
[5] So S.K.S., Chang P.N., Najarian J.S., Mauer S.M., Simmens R.L., Nevins T.E., Growth and development in infants after renal transplantation, J Pediatr, 110, pp. 343-350, (1987)
[6] Van Dop C., Jabs K.L., Donohoue P.A., Bock G.H., Fivush B.A., Harmon W.E., Accelerated growth rates in children treated with growth hormone after renal transplantation, J Pediatr, 120, pp. 244-250, (1992)
[7] Benfield, Parker K.L., Waldo F.B., Overstreet S.L., Kohaut E.C., Treatment of growth failure in children after renal transplantation, Transplantation, 55, pp. 305-308, (1993)
[8] Fine R.N., Yadin O., Nelson P.A., Pyke-Grimm K., Boechat M.I., Lippe B.H., Sherman B.M., Ettenger R.B., Kamil E., Recombinant human growth hormone treatment of children following renal transplantation, Pediatr Nephrol, 5, pp. 147-151, (1991)
[9] Benfield, Parker K.L., Waldo F.B., Overstreet S.L., Kohaut E.C., Growth hormone in the treatment of growth failure in children after renal transplantation, Kidney Int, 44, pp. S62-S64, (1993)
[10] Jabs K., Van Dop C., Harmon W., Growth hormone treatment of growth failure among children with renal transplants, Kidney Int, 44, pp. S71-S75, (1993)

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