ANTIRHINOVIRUS ACTIVITY OF 6-ANILINO-9-BENZYL-2-CHLORO-9H-PURINES

被引：8

作者：

KELLEY, JL ^{[1
]}

LINN, JA ^{[1
]}

SELWAY, JWT ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 05期

关键词：

D O I：

10.1021/jm00167a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes. © 1990, American Chemical Society. All rights reserved.

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页码：1360 / 1363

页数：4

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