LEAKAGE OF FLUID ADMINISTERED EPIDURALLY TO RATS INTO SUBCUTANEOUS TISSUE

被引：7

作者：

PLUMMER, JL ^{[1
]}

CMIELEWSKI, PL ^{[1
]}

GOURLAY, GK ^{[1
]}

CHERRY, DA ^{[1
]}

COUSINS, MJ ^{[1
]}

SZEP, PF ^{[1
]}

DAVIES, RP ^{[1
]}

机构：

[1] FLINDERS UNIV,MED CTR,DEPT RADIOL,BEDFORD PK,SA 5042,AUSTRALIA

来源：

PAIN | 1990年 / 42卷 / 01期

基金：

英国医学研究理事会;

关键词：

Cannulation; Epidural catheter; Leakage;

D O I：

10.1016/0304-3959(90)91097-3

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Epidural catheters were implanted in rats under halothane/nitrous oxide anaesthesia. Contrast medium (Iopamidol®) was injected via the catheter under fluoroscopic control 24-48 h after implantation. In 15 of 20 rats contrast could be seen leaking out of the epidural space, usually after only 25 μl was administered. Leakage was associated with diminished antinociceptive response to morphine administered via the catheter. Both leakage and decreased response to morphine could be largely prevented by applying a drop of Supa-Glue® over the site of entry of the catheter to the epidural space at the time of catheter implantation. Investigators using epidurally cannulated rats should document that leakage does not occur or discard results from rats showing evidence of leakage. © 1990.

引用

页码：121 / 124

页数：4

共 4 条

[1] CHRONIC CANNULATION OF THE INTRADURAL OR EXTRADURAL SPACE IN THE RAT [J].

BAHAR, M ;

ROSEN, M ;

VICKERS, MD .

BRITISH JOURNAL OF ANAESTHESIA, 1984, 56 (04) :405-410

[2] EPIDURAL ADMINISTRATION OF MORPHINE FOR CONTROL OF CANCER PAIN - LONG-TERM EFFICACY AND COMPLICATIONS [J].

DRIESSEN, JJ ;

DEMULDER, PHM ;

CLAESSEN, JJL ;

VANDIEJEN, D ;

WOBBES, T .

CLINICAL JOURNAL OF PAIN, 1989, 5 (03) :217-222

[3] EPIDURAL INJECTIONS OF BUPIVACAINE, MORPHINE, FENTANYL, LOFENTANIL, AND DADL IN CHRONICALLY IMPLANTED RATS - A PHARMACOLOGICAL AND PATHOLOGICAL-STUDY [J].

DURANT, PAC ;

YAKSH, TL .

ANESTHESIOLOGY, 1986, 64 (01) :43-53

[4] LONG-TERM CATHETERIZATION OF THE LUMBAR EPIDURAL SPACE IN RATS [J].

VANDENHOOGEN, RHWM ;

COLPAERT, FC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 15 (03) :515-516

← 1 →