REGULATION OF THE INDUCTION OF ALKALINE-PHOSPHATASE IN CHORIOCARCINOMA CELLS BY SODIUM-BUTYRATE

被引：16

作者：

CHOU, JY

机构：

[1] Laboratory of Biomedical Sciences, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, 20014, Maryland, Building 6

来源：

IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION | 1979年 / 15卷 / 10期

关键词：

alkaline phosphatase; choriocarcinoma cells; sodium butyrate;

D O I：

10.1007/BF02618305

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Alkaline phosphatase is induced in human choriocarcinoma cells by short-chain fatty acids, especially sodium butyrate. This fatty acid increases the phosphatase activity immediately and in a nearly linear fashion. Only phosphatase with an alkaline pH optimum is induced. Both the induced alkaline phosphatase and the basal enzyme are precipitated by antiserum against term-placental alkaline phosphatase, but the choriocarcinoma phosphatase is less stable to heating than is the term-placental enzyme. The induction of alkaline phosphatase activity requires cellular synthesis of protein, RNA and DNA. The regulation of induction probably occurs at the transcriptional level. © 1979 Tissue Culture Association.

引用

页码：789 / 795

页数：7

共 26 条

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