NITRIC-OXIDE IS REQUIRED FOR TACTILE LEARNING IN OCTOPUS-VULGARIS

被引：64

作者：

ROBERTSON, JD

BONAVENTURA, J

KOHM, AP

机构：

[1] DUKE UNIV, MED CTR, DEPT CELL BIOL, DURHAM, NC 27710 USA

[2] DUKE UNIV, SCH ENVIRONM, MARINE LAB, BEAUFORT, NC 28516 USA

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1994年 / 256卷 / 1347期

关键词：

D O I：

10.1098/rspb.1994.0080

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide, produced by nitric oxide synthase in brain tissue, is essential for several different kinds of learning in vertebrates. We present the first evidence that it is also essential for learning in an invertebrate. Intramuscular injections of an inhibitor of the enzyme completely block touch learning in Octopus vulgaris. Eight control animals learned a touch paradigm, but none of eight synthase-inhibited ones learned it.

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页码：269 / 273

页数：5

相关论文

共 34 条

[1]

Alkon D. L., 1987, MEMORY TRACES BRAIN

[2] A PHYSIOLOGICAL-BASIS FOR A THEORY OF SYNAPSE MODIFICATION [J].

BEAR, MF ;

COOPER, LN ;

EBNER, FF .

SCIENCE, 1987, 237 (4810) :42-48

[3]

BLISS TVP, 1991, LONG TERM POTENTIATI

[4] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BOHME, GA ;

BON, C ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 199 (03) :379-381

[5] ALTERED SYNAPTIC PLASTICITY AND MEMORY FORMATION IN NITRIC-OXIDE SYNTHASE INHIBITOR-TREATED RATS [J].

BOHME, GA ;

BON, C ;

LEMAIRE, M ;

REIBAUD, M ;

PIOT, O ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :9191-9194

[6] CLONED AND EXPRESSED NITRIC-OXIDE SYNTHASE STRUCTURALLY RESEMBLES CYTOCHROME-P-450 REDUCTASE [J].

BREDT, DS ;

HWANG, PM ;

GLATT, CE ;

LOWENSTEIN, C ;

REED, RR ;

SNYDER, SH .

NATURE, 1991, 351 (6329) :714-718

[7] NITRIC-OXIDE - A PHYSIOLOGICAL MEDIATOR OF PENILE ERECTION [J].

BURNETT, AL ;

LOWENSTEIN, CJ ;

BREDT, DS ;

CHANG, TSK ;

SNYDER, SH .

SCIENCE, 1992, 257 (5068) :401-403

[8] INHIBITION OF NITRIC-OXIDE SYNTHESIS IMPAIRS 2 DIFFERENT FORMS OF LEARNING [J].

CHAPMAN, PF ;

ATKINS, CM ;

ALLEN, MT ;

HALEY, JE ;

STEINMETZ, JE .

NEUROREPORT, 1992, 3 (07) :567-570

[9] SELECTIVE VULNERABILITY OF THE BRAIN - NEW INSIGHTS INTO THE PATHO-PHYSIOLOGY OF STROKE [J].

COLLINS, RC ;

DOBKIN, BH ;

CHOI, DW .

ANNALS OF INTERNAL MEDICINE, 1989, 110 (12) :992-1000

[10] IS NITRIC-OXIDE (NO) PRODUCED BY INVERTEBRATE NEURONS [J].

ELOFSSON, R ;

CARLBERG, M ;

MOROZ, L ;

NEZLIN, L ;

SAKHAROV, D .

NEUROREPORT, 1993, 4 (03) :279-282

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