ALPHA-SUBUNIT OF BETA-CONGLYCININ, AN ALLERGENIC PROTEIN RECOGNIZED BY IGE ANTIBODIES OF SOYBEAN-SENSITIVE PATIENTS WITH ATOPIC-DERMATITIS

被引:124
作者
OGAWA, T
BANDO, N
TSUJI, H
NISHIKAWA, K
KITAMURA, K
机构
[1] NATL KAGAWA CHILDRENS HOSP, ZENTSUJI 765, JAPAN
[2] NATL AGR RES CTR, LEGUME BREEDING LAB, TSUKUBA, IBARAKI 305, JAPAN
关键词
D O I
10.1271/bbb.59.831
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
One of the major allergenic proteins in the soybean 7S-globulin fraction, which was recognized by sera of about 25% soybean-sensitive patients with atopic dermatitis, was identified as alpha-subunit of beta-conglycinin. The IgE antibodies recognizing the alpha-subunit did not show a cross-reactivity against both alpha'- and beta-subunits known to be highly homologous to alpha-subunit, and also against other allergenic components identified in soybeans [Ogawa et al., J, Nutr. Sci, Vitaminol., 35, 555-565 (1993)]. The IgE-binding site(s) was estimated to be located on the peptide 232-383 of alpha-subunit.
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收藏
页码:831 / 833
页数:3
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