Studies of the acuity-luminance function are reported for patients with reduced acuity resulting from optic nerve lesions, suppression amblyopias and retinal lesions of various sorts. The findings in all patients of the first two groups and in some of those with retinal lesions can be attributed almost entirely to the use of parafoveal or paramacular regions of the retina. The excentric viewing area is associated with a reduced rate of change of acuity with log luminance similar to that observed in the normal para-central retina. In some patients with retinal pathology involving the macular area the entire acuity-log I graph is shifted to the right on the intensity axis. As a result these patients require very high light intensities to attain their best visual acuity. © 1969 Dr. W. Junk N.V.