ENHANCED PGE PRODUCTION BY MAF-TREATED PERITONEAL EXUDATE MACROPHAGES

被引：28

作者：

FRIEDMAN, SA

REMOLDODONNELL, E

PIESSENS, WF

机构：

[1] ROBERT B BRIGHAM HOSP,BOSTON,MA 02120

[2] HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

来源：

CELLULAR IMMUNOLOGY | 1979年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0008-8749(79)90237-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Guinea pig peritoneal macrophages were activated in vitro by culturing with MAF (macrophage activating factor)-containing fractions from stimulated lymphocytes. These macrophage preparations demonstrate a 60% increase in the production of prostaglandins of the E series (PGE) when compared with macrophages cultured with fractions from unstimulated lymphocytes. PGE accumulation in macrophage cultures is maximal after 24 hr with MAF; tumor cytotoxicity is also maximal at this time. The final PGE concentration in cultures of activated macrophages averaged 3 × 10-8M. © 1979.

引用

页码：213 / 218

页数：6

共 22 条

[1] MODULATION OF INFLAMMATION AND IMMUNITY BY CYCLIC-AMP
BOURNE, HR
LICHTENSTEIN, LM
MELMON, KL
HENNEY, CS
WEINSTEIN, Y
SHEARER, GM
[J]. SCIENCE, 1974, 184 (4132) : 19 - 28
[2] CHURCHILL WH, 1975, J IMMUNOL, V115, P781
[3] RELEASE OF PROSTAGLANDIN BY MITOGEN-STIMULATED AND ANTIGEN-STIMULATED LEUKOCYTES IN CULTURE
FERRARIS, VA
DERUBERT.FR
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1974, 54 (02) : 378 - 386
[4] GEMSA D, 1978, J IMMUNOL, V120, P1187
[5] CONTROL OF LYMPHOKINE SECRETION BY PROSTAGLANDINS
GORDON, D
BRAY, MA
MORLEY, J
[J]. NATURE, 1976, 262 (5567) : 401 - 402
[6] HERBERT V, 1976, HORMONES HUMAN BLOOD, P115
[7] HIBBS JB, 1972, P SOC EXP BIOL MED, V139, P1049
[8] HONG SCL, 1976, J BIOL CHEM, V251, P776
[9] MACROPHAGES SYNTHESIZE AND RELEASE PROSTAGLANDINS IN RESPONSE TO INFLAMMATORY STIMULI
HUMES, JL
BONNEY, RJ
PELUS, L
DAHLGREN, ME
SADOWSKI, SJ
KUEHL, FA
DAVIES, P
[J]. NATURE, 1977, 269 (5624) : 149 - 151
[10] RADIOIMMUNOASSAY MEASUREMENT OF PROSTAGLANDINS-E, A, AND F IN HUMAN PLASMA
JAFFE, BM
BEHRMAN, HR
PARKER, CW
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (02) : 398 - 405

← 1 2 3 →