INTERICTAL SPIKES AND HIPPOCAMPAL SOMATOSTATIN LEVELS IN TEMPORAL-LOBE EPILEPSY

被引：25

作者：

DEUTCH, C

SPENCER, S

ROBBINS, R

CICCHETTI, D

SPENCER, D

机构：

[1] YALE UNIV,SCH MED,DEPT NEUROL,333 CEDAR ST,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT MED,NEW HAVEN,CT 06510

[3] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510

[4] YALE UNIV,SCH MED,DEPT SURG,NEW HAVEN,CT 06510

[5] VET ADM MED CTR,W HAVEN,CT 06516

来源：

EPILEPSIA | 1991年 / 32卷 / 02期

关键词：

SOMATOSTATIN; EPILEPSY; INTERICTAL SPIKES; HIPPOCAMPUS; ENTORHINAL CORTEX;

D O I：

10.1111/j.1528-1157.1991.tb05241.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the relationship between somatostatin-like immunoreactivity (SSLI) and interictal spikes (IIS) in human temporal lobe epileptic tissue. IIS counted manually from depth electrode recordings obtained preoperatively were expressed as spike frequency in anterior, middle, and posterior portions of hippocampus. SSLI was determined by radioimmunoassay (RIA). An inverse relationship between SSLI in the entorhinal cortex (EC) and IIS frequency in hippocampus was present (r = -0.55, p = 0.06). No correlation between IIS and SSLI in CA4, CA3, CA1, or the dentate was evident. This finding suggests a role of the EC in generation, regulation, or expression of interictal paroxysmal electrical activity in temporal lobe epilepsy (TLE), for which somatostatin may be a marker.

引用

页码：174 / 178

页数：5

共 21 条

[1] INHIBITORY EFFECTS OF MOTILIN, SOMATOSTATIN, [LEU]ENKEPHALIN, [MET]ENKEPHALIN, AND TAURINE ON NEURONS OF THE LATERAL VESTIBULAR NUCLEUS - INTERACTIONS WITH GAMMA-AMINOBUTYRIC ACID [J].