PRELIMINARY-REPORT ON THE USE OF DESFERRIOXAMINE IN THE TREATMENT OF PLASMODIUM-FALCIPARUM MALARIA

被引：45

作者：

TRAORE, O

CARNEVALE, P

KAPTUENOCHE, L

MBEDE, J

DESFONTAINE, M

ELION, J

LABIE, D

NAGEL, RL

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DIV HEMATOL,1300 MORRIS PK AVE,BRONX,NY 10461

[2] CHU R DEBRE,INSERM,U120,PARIS,FRANCE

[3] CHU COCHIN,INSERM,U15,F-75674 PARIS 14,FRANCE

[4] MINIST HLTH,YAOUNDE,CAMEROON

[5] ORG COOPERAT ENDEMIES AFRIQUE CENT,YAOUNDE,CAMEROON

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1991年 / 37卷 / 03期

关键词：

CHLOROQUINE; PARASITEMIA; PARASITIZED RED CELLS;

D O I：

10.1002/ajh.2830370316

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The administration of 0.5 g (IM) of desferrioxamine every 12 hr for 3 days with 25 mg/kg (total dose for three days) of chloroquine abated the parasitemia of Plasmodium falciparum infected individuals more rapidly than chloroquine alone. Two patients with in vitro evidence of total or partial resistance to chloroquine also were successfully treated with the combination of drugs, and were free of parasitized red cells by day 7. Further clinical trials and development of desferrioxamine in the treatment of P. falciparum are warranted.

引用

页码：206 / 208

页数：3

共 5 条

[1] PLASMODIUM-VINCKEI - SUPPRESSION OF MOUSE INFECTIONS WITH DESFERRIOXAMINE-B [J].