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THE PARADOX OF NICOTINIC ACETYLCHOLINE-RECEPTOR UP-REGULATION BY NICOTINE

被引：324
作者：
WONNACOTT, S
机构：
[1] Department of Biochemisty, University of Bath, Bath
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 06期
关键词：
D O I：
10.1016/0165-6147(90)90242-Z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including denervation) produces an upregulation of receptors. © 1990.
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页码：216 / 219
页数：4
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