TOWARDS A MOLECULAR UNDERSTANDING OF T-CELL DIFFERENTIATION

被引：29

作者：

CLEVERS, HC ^{[1
]}

OWEN, MJ ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,IMPERIAL CANC RES FUND LABS,LONDON EC1A 7BE,ENGLAND

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0167-5699(91)90163-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphoid differentiation is one of the best studied examples of mammalian development. Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes. Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.

引用

页码：86 / 92

页数：7

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