CHARACTERIZATION OF THE OPPOSITE-STRAND GENES FROM THE MOUSE BIDIRECTIONALLY TRANSCRIBED HTF9 LOCUS

被引：41

作者：

BRESSAN, A

SOMMA, MP

LEWIS, J

SANTOLAMAZZA, C

COPELAND, NG

GILBERT, DJ

JENKINS, NA

LAVIA, P

机构：

[1] UNIV ROME LA SAPIENZA,CNR,CTR GENET EVOLUZIONIST,DIPARTIMENTO GENET & BIOL MOLEC,I-00185 ROME,ITALY

[2] NCI,FREDERICK CANC RES & DEV CTR,MAMMALIAN GENET LAB,ABL BASIC RES PROGRAM,FREDERICK,MD 21702

[3] INST MOLEC PATHOL,VIENNA,AUSTRIA

来源：

GENE | 1991年 / 103卷 / 02期

关键词：

CPG ISLAND; GENE MOLECULAR ORGANIZATION; BIDIRECTIONAL TRANSCRIPTION; HOUSEKEEPING EXPRESSION; NUCLEOTIDE SEQUENCE; INTERSPECIFIC BACKCROSS MAPPING;

D O I：

10.1016/0378-1119(91)90274-F

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse HTF9 locus contains two genes that are bidirectionally transcribed with opposite polarity from a shared CpG-rich island. Both genes were previously shown to be expressed in a housekeeping fashion in mouse. We have now determined the molecular organization of the genes over 12 kb surrounding the island. In addition, we show that the HTF9 locus resides in the proximal region of mouse chromosome 16. We have sequenced the cDNAs corresponding to both divergent transcripts. Both genes appear to code for novel proteins that are structurally unrelated to each other. Finally, we show that both genes are highly conserved and efficiently expressed in human cells.

引用

页码：201 / 209

页数：9

共 30 条

[1] SPECIFIC PROTECTION OF METHYLATED CPGS IN MAMMALIAN NUCLEI [J].