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RAR-BETA-4, A RETINOIC ACID RECEPTOR ISOFORM IS GENERATED FROM RAR-BETA-2 BY ALTERNATIVE SPLICING AND USAGE OF A CUG INITIATOR CODON

被引：116
作者：
NAGPAL, S
ZELENT, A
CHAMBON, P
机构：
[1] Lab. Genet. Molec. Eucaryotes CNRS, U. 184 Biol. Molec. Genetique INSERM, Institut de Chimie Biologique
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 07期
关键词：
RETINOIC ACID-INDUCIBLE; NON-AUG INITIATOR CODON; SPECIFIC EXPRESSION; DEVELOPMENT;
D O I：
10.1073/pnas.89.7.2718
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An isoform of retinoic acid receptor beta, RAR-beta-4, has been identified. RAR-beta-4 is expressed under the control of the same retinoic acid-responsive promoter as RAR-beta-2. RAR-beta-4, which is generated by alternative splicing from the same primary transcripts as RAR-beta-2, is initiated by a non-AUG codon, CUG. The amino acid sequence of RAR-beta-4 in regions B-F is identical to that of the other RAR-beta isoforms beta-1, beta-2, and beta-3. However, the RAR-beta-4 A region is much shorter (4 amino acids long) than those of these isoforms. RAR-beta-4 exhibits a tissue-specific pattern of expression and distinct transcriptional activation properties when compared with the other RAR-beta isoforms.
引用
收藏
页码：2718 / 2722
页数：5
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