DAPTOMYCIN DISRUPTS MEMBRANE-POTENTIAL IN GROWING STAPHYLOCOCCUS-AUREUS

被引：169

作者：

ALBORN, WE

ALLEN, NE

PRESTON, DA

机构：

[1] Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 11期

关键词：

D O I：

10.1128/AAC.35.11.2282

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (DELTA-PSI) in Staphylococcus aureus without noticeably affecting the chemical gradient (DELTA-pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available DELTA-PSI.

引用

页码：2282 / 2287

页数：6

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