THE GLYCOPROTEASE OF PASTEURELLA-HAEMOLYTICA-A1 ELIMINATES BINDING OF MYELOID CELLS TO P-SELECTIN BUT NOT TO E-SELECTIN

被引：48

作者：

STEININGER, CN

EDDY, CA

LEIMGRUBER, RM

MELLORS, A

WELPLY, JK

机构：

[1] MONSANTO CO,MONSANTO CORP RES,ST LOUIS,MO 63167

[2] UNIV GUELPH,GUELPH WATERLOO CTR GRAD WORK CHEM,GUELPH N1G 2W1,ONTARIO,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91121-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HL-60 cells and neutrophils treated with the glycoprotease from Pasteurella haemolytica A1, an enzyme which is specific for O-sialoglycoproteins, were found to be incapable of binding P-selectin but still bound E-selectin. Comparative analysis of [35-S] cysteine labeled proteins from HL-60 cells by 2-dimensional electrophoresis indicated that two major proteins with Mr 100 and 115 kd were significantly removed from cells which had been treated. © 1992.

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页码：760 / 766

页数：7

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