STRUCTURAL-ANALYSIS OF INVASION PLASMID ANTIGEN-D (IPAD) FROM SHIGELLA-FLEXNERI

被引：21

作者：

MARQUART, ME ^{[1
]}

PICKING, WL ^{[1
]}

PICKING, WD ^{[1
]}

机构：

[1] ST LOUIS UNIV,DEPT BIOL,ST LOUIS,MO 63103

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2380

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Invasion plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri invasive phenotype; however, little is known of the structural properties of these essential virulence components. Biochemical data suggest IpaB, C, and D present in S. flexneri OMPs form soluble protein complexes and IpaD may be able to form large homopolymeric complexes. (C) 1995 Academic Press, Inc.

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页码：963 / 970

页数：8

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