HEMIASTERLIN AND GEODIAMOLIDE-TA - 2 NEW CYTOTOXIC PEPTIDES FROM THE MARINE SPONGE HEMIASTERELLA-MINOR (KIRKPATRICK)

Three cytotoxic peptides, Jaspamide (1) and the two new peptides hemiasterlin (2) and geodiamolide TA (3), have been isolated from the sponge Hemiasterella minor. The structures of the three were determined by interpretating the NMR and mass spectra. Hemiasterlin (2) is a novel linear tripeptide embodying two unique, new natural aminoacids and geodiamolide TA (3) is a higher homologe of geodiamolides A-F.