EFFECTS OF HIGH-DOSES OF A SERIES OF NEW LUTEINIZING-HORMONE-RELEASING HORMONE ANALOGS IN INTACT FEMALE RATS

被引:45
作者
MAYNARD, PV
NICHOLSON, RI
机构
[1] Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff
关键词
D O I
10.1038/bjc.1979.51
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A new series of LH-RH [luteinizing hormone releasing hormone] analogs [antineoplastic-drugs] containing an Azgly10 [azaglycine residue in position 10] modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH [luteinizing hormone] and FSH [follicle stimulating hormone] were raised to extremely high levels after 14 days administration of the compounds (5.0 and 0.5 .mu.g/rat twice daily), but plasma estradiol concentrations were reduced to those in ovariectomized rats. The weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treatment regime, producing the effects of chemical castration.
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页码:274 / 279
页数:6
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