EFFECT OF LOCAL-ANESTHETICS ON MITOCHONDRIAL-MEMBRANE POTENTIAL IN LIVING CELLS

被引：69

作者：

GROUSELLE, M

TUEUX, O

DABADIE, P

GEORGESCAUD, D

MAZAT, JP

机构：

[1] CNRS, INST BIOCHIM CELLULAIRE & NEUROCHIM, 1 RUE CAMILLE ST SAENS, F-33077 BORDEAUX, FRANCE

[2] CNRS, CTR RECH PAUL PASCAL, F-33600 PESSAC, FRANCE

[3] UNIV BORDEAUX 2, DEPT MED BIOCHEM & MOLEC BIOL, F-33076 BORDEAUX, FRANCE

来源：

BIOCHEMICAL JOURNAL | 1990年 / 271卷 / 01期

关键词：

D O I：

10.1042/bj2710269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the laser dye rhodamine 123, we demonstrated that local anaesthetics can reach mitochondria in cell culture and reversibly decrease, or even collapse, their transmembrane potential. This effect is highly dependent on the lipid-solubility of the local anaesthetic and can be facilitated by the presence of a lipophilic anion.

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页码：269 / 272

页数：4

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