GROWTH-HORMONE GENE-REGULATION - A PARADIGM FOR CELL-TYPE-SPECIFIC GENE ACTIVATION

被引：94

作者：

KARIN, M

CASTRILLO, JL

THEILL, LE

机构：

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1016/0168-9525(90)90100-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The growth hormone (GH) gene is specifically expressed within specialized cells of the anterior pituitary. The central role in GH gene activation is played by GHF-1, a homeodomain protein that is itself specifically expressed in the anterior pituitary. © 1990.

引用

收藏

页码：92 / 96

页数：5

相关论文

共 34 条

[1]

ANGEL P, 1989, New Biologist, V1, P35

[2] DWARF MICE PRODUCED BY GENETIC ABLATION OF GROWTH HORMONE-EXPRESSING CELLS [J].

BEHRINGER, RR ;

MATHEWS, LS ;

PALMITER, RD ;

BRINSTER, RL .

GENES & DEVELOPMENT, 1988, 2 (04) :453-461

[3] A PITUITARY-SPECIFIC TRANS-ACTING FACTOR CAN STIMULATE TRANSCRIPTION FROM THE GROWTH-HORMONE PROMOTER IN EXTRACTS OF NONEXPRESSING CELLS [J].

BODNER, M ;

KARIN, M .

CELL, 1987, 50 (02) :267-275

[4] THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-GHF-1 IS A HOMEOBOX-CONTAINING PROTEIN [J].

BODNER, M ;

CASTRILLO, JL ;

THEILL, LE ;

DEERINCK, T ;

ELLISMAN, M ;

KARIN, M .

CELL, 1988, 55 (03) :505-518

[5] TRANSGENIC MICE WITH INDUCIBLE DWARFISM [J].

BORRELLI, E ;

HEYMAN, RA ;

ARIAS, C ;

SAWCHENKO, PE ;

EVANS, RM .

NATURE, 1989, 339 (6225) :538-541

[6] PURIFICATION OF GROWTH-HORMONE SPECIFIC TRANSCRIPTION FACTOR GHF-1 CONTAINING HOMEOBOX [J].

CASTRILLO, JL ;

BODNER, M ;

KARIN, M .

SCIENCE, 1989, 243 (4892) :814-817

[7]

CHATELAIN A, 1979, CELL TISSUE RES, V196, P409

[8] IDENTIFICATION OF AN ADENOSINE-3',5'-MONOPHOSPHATE (CAMP)-RESPONSIVE REGION IN THE RAT GROWTH-HORMONE GENE - EVIDENCE FOR INDEPENDENT AND SYNERGISTIC EFFECTS OF CAMP AND THYROID-HORMONE ON GENE-EXPRESSION [J].

COPP, RP ;

SAMUELS, HH .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (05) :790-796

[9] ANALYSIS OF SP1 INVIVO REVEALS MULTIPLE TRANSCRIPTIONAL DOMAINS, INCLUDING A NOVEL GLUTAMINE-RICH ACTIVATION MOTIF [J].

COUREY, AJ ;

TJIAN, R .

CELL, 1988, 55 (05) :887-898

[10] INDUCTION OF HUMAN GROWTH-HORMONE PROMOTER ACTIVITY BY THE ADENOSINE-3',5'-MONOPHOSPHATE PATHWAY INVOLVES A NOVEL RESPONSIVE ELEMENT [J].

DANA, S ;

KARIN, M .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (05) :815-821

← 1 2 3 4 →