MUTATION-INDUCTION IN CHINESE HAMSTER LUNG V79 CELLS BY 5 ALK-2-ENALS PRODUCED BY LIPID-PEROXIDATION

被引：28

作者：

CANONERO, R

MARTELLI, A

MARINARI, UM

BRAMBILLA, G

机构：

[1] UNIV GENOA,INST PHARMACOL,VIALE BENEDETTO XV 2,I-16132 GENOA,ITALY

[2] UNIV GENOA,INST GEN PATHOL,I-16132 GENOA,ITALY

来源：

MUTATION RESEARCH | 1990年 / 244卷 / 02期

关键词：

Alk-2-enals; Genotoxic effects; Induction by alk-2-enals of 6-thioguanine-resistant mutants; Lipid peroxidation products; Mutagenic activity in mammalian cells;

D O I：

10.1016/0165-7992(90)90065-R

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Five alk-2-enals - pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal - produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency of 6-thioguanine-resistant mutants, and their mutagenic potency was found to increase with the length of the carbon chain. In contrast, only hept-2-enal produced a statistically significant increase in the number of mutations to ouabain resistance. © 1990.

引用

页码：153 / 156

页数：4

共 15 条

[1]

AMES BN, 1982, LIPID PEROXIDES BIOL, P339

[2] MUTAGENESIS BY CHEMICAL-AGENTS IN V79 CHINESE-HAMSTER CELLS - A REVIEW AND ANALYSIS OF THE LITERATURE - A REPORT OF THE GENE-TOX PROGRAM [J].