OCCURRENCE AND DISTRIBUTION OF NON-NMDA GLUTAMATE RECEPTOR MESSENGER-RNAS IN THE COCHLEA

被引：46

作者：

RYAN, AF

BRUMM, D

KRAFT, M

机构：

[1] VET ADM MED CTR,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,SCH MED,DEPT NEUROSCI,LA JOLLA,CA 92093

来源：

NEUROREPORT | 1991年 / 2卷 / 11期

关键词：

NEURONAL RECEPTORS; GLUTAMATE; INNER EAR; INSITU MESSENGER RNA HYBRIDIZATION;

D O I：

10.1097/00001756-199111000-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE expression of mRNAs encoding five putative non-NMDA glutamate receptors was investigated using in situ hybridization with radiolabeled riboprobes. Hybridization was observed in spiral ganglion neurons with probes complementary to mRNA products of the glutamate receptor genes GluR2 and GluR3. No specific hybridization was observed with probes for GluR1, GluR4 or GluR5. The results support the hypothesis that glutamate is the transmitter between cochlear inner hair cells and spiral ganglion neurons, and that it acts via non-NMDA glutamate receptors.

引用

页码：643 / 646

页数：4

共 25 条

[1] IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUTAMATE IMMUNOREACTIVITY IN THE GUINEA-PIG COCHLEA [J].