TREATMENT OF PIGMENTED VILLONODULAR SYNOVITIS WITH Y-90 - CHANGES IN IMMUNOLOGICAL FEATURES, TC-99M UPTAKE MEASUREMENTS, AND MR IMAGING OF ONE CASE

被引：17

作者：

CHEN, DY

LAN, JL

CHOU, SJ

机构：

[1] Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, No. 160, Section 3, Chung-Kang Road

来源：

CLINICAL RHEUMATOLOGY | 1992年 / 11卷 / 02期

关键词：

PIGMENTED VILLONODULAR SYNOVITIS; Y-90; LYMPHOCYTE SUBSETS; TC-99M PERTECHNETATE UPTAKE; MR IMAGING;

D O I：

10.1007/BF02207973

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pigmented villonodular synovitis (PVNS) is an uncommon proliferative disease of synovium. We report a 35-year-old male with diffuse form of PVNS of left knee, treated with intraarticular injection of 5 mCi of yttrium-90 (Y-90) silicate colloid consisting of two doses with a 3-month interval between them. During follow-up, the affected knee showed clinical improvement and was accompanied by a decrease of the levels of soluble interleukin-2 receptor in sera and synovial fluids (SF). When compared to osteoarthritis subjects, SF lymphocyte subsets of this case before Y-90 therapy showed a lower CD4: CD8 cell ratio and absence of suppressor inducer cells (CD4+ 2H4+). The Tc-99m pertechnetate knee uptake indexes correlated well with clinical improvement. Serial magnetic resonance imaging revealed significant change one year after Y-90 therapy. The findings of immunological assessment suggested that immunoregulatory dysfunction may be related to the pathogenesis of PVNS.

引用

页码：280 / 285

页数：6

共 27 条

[1]

Docken W.P., Pigmented villonodullar synovitis: review with illustrative case reports, Semin Arthritis Rheum, 9, pp. 1-22, (1979)

[2]

Myers B.W., Masi A.T., Feigenbaum S.L., Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review, Medicine (Baltimore), 59, pp. 223-238, (1980)

[3]

Granowitz S.P., D'Antonio J., Mankin H.L., The pathogenesis and long-term end results of pigmented villonodular synovitis, Clin Orthop, 114, pp. 335-351, (1976)

[4]

Hirohata, Kazushi, Light microscopic and electron microscopic studies of individual cells in pigmented villonodular synovitis and bursitis, Kobe J Med Sci, 14, pp. 251-279, (1968)

[5]

Jaffe H.L., Lichtenstein, Louis, Sutro C.J., Pigmented villonodular synovitis, bursitis, and tenosynovitis, Arch Pathol, 31, pp. 731-765, (1941)

[6]

Byers P.D., Cotton R.E., Deacon O.W., Et al., The diagnosis and treatment of pigmented villonodular synovitis, J Bone Joint Surg, 50, pp. 290-305, (1968)

[7]

Johansson J.E., Ajjoub S., Coughlin L.P., Wener J.A., Cruess R.L., Pigmented villonodular synovitis of joints, Clin Orthop, 163, pp. 159-166, (1982)

[8]

Rao A.S., Vigorita M.J., Pigmented villonodular synovitis (Giant-cell tumor of tendon sheath and synovial membrane): a review of eighty one cases, J Bone Joint Surg, 66 A, pp. 76-94, (1984)

[9]

Wiss D.A., Recurrent villonodular synovitis of the knee: successful treatment with yttrium-90, Clin Orthop, 169, pp. 139-144, (1982)

[10]

O'Sullivan M.M.O., Yates D.B., Pritchard M.H., Yttrium 90 synovectomy: a new treatment for pigmented villonodular synovitis, Br J Rheumatol., 26, pp. 71-72, (1987)

← 1 2 3 →